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MCL Research on Kidney Segmentation

Kidney cancer is one of the most common malignancies of the urinary system. To detect kidney cancer, we must identify kidney tumors, which can vary significantly in size, shape, and biological behavior, ranging from benign lesions to aggressive malignant tumors that require timely diagnosis and treatment. Accurate identification and segmentation of kidney tumors on CT or MRI scans are essential for clinical decision-making, surgical planning, and prognosis assessment.

We have recently been developing a framework called Green U-shaped Learning (GUSL) for kidney and tumor segmentation. This is a two-stage framework. In Stage 1, we performed segmentation of the kidney organ, and in Stage 2, we cropped the kidney region as the region of interest (ROI) for tumor segmentation. We employ our GUSL framework on both stages, which could achieve fine-to-coarse feature extraction and coarse-to-fine residual correction. 

By |November 16th, 2025|News|Comments Off on MCL Research on Kidney Segmentation|

MCL Research on Seismic Data Processing

Earthquakes generate seismic waves that travel through the Earth’s interior, carrying critical information about the Earth’s structure and the source event. These waves are mainly divided into two types: P-waves and S-waves. P-waves, or primary waves, travel fastest and arrive first at seismic stations, while S-waves, or secondary waves, follow with a slower speed but higher amplitude, often causing greater damage. Accurately identifying the arrival times of these waves — a process known as phase picking — is fundamental for earthquake localization, magnitude estimation, and early warning systems. However, seismic recordings are often contaminated by complex background noise, overlapping signals, and variable station conditions, which make manual picking both time-consuming and subjective. Automated phase picking, therefore, plays an increasingly vital role in modern seismology, enabling real-time earthquake detection and large-scale waveform analysis. Despite significant progress, achieving high precision and robustness across diverse seismic environments remains a major challenge for automated systems.

GreenPhase is a multi-resolution Green Learning framework for seismic phase picking. It aims to achieve high accuracy while maintaining interpretability and computational efficiency. The model operates across three resolution levels — from coarse to fine — progressively narrowing down candidate regions for P and S arrivals. At each level, GreenPhase extracts spectral–temporal features using the Saab transform and refines them through supervised feature selection and XGBoost regression. A pseudo-label generation and balanced sampling strategy further enhance training stability. Compared with deep networks such as PhaseNet and EQTransformer, GreenPhase requires far fewer training samples while achieving comparable performance. It is trained in a fully feedforward manner, balancing performance, efficiency, and interpretability. For the detection task, GreenPhase achieves an F1 score of 1.00; for P-phase picking, 0.98; and for S-phase picking, 0.96. The differences from EQTransformer, [...]

By |November 9th, 2025|News|Comments Off on MCL Research on Seismic Data Processing|

MCL Research on Mice Navigation Pattern Strategies

Understanding how animals navigate and learn from their environments has long been a central question in neuroscience. The Morris Water Maze (MWM) is one of the most widely used paradigms for studying spatial learning and memory in rodents. Traditionally, researchers have assessed performance using simple metrics such as escape latency and total path length. While these measures quantify task efficiency, they fail to capture the diversity of navigation strategies that rodents employ within a single trial. Recent work has revealed that mice often transition dynamically between different behavioral modes, such as thigmotaxis, scanning target, and direct search, suggesting that whole-trajectory analyses may overlook important within-trial strategy shifts.

To address this, we develop a Green Learning (GL) based framework to classify sub-trajectories into expert-defined behavioral strategies in an energy-efficient and interpretable manner. Unlike deep learning methods that depend on large datasets, backpropagation, and heavy computation, GL employs a feedforward-designed architecture emphasizing energy efficiency, logical transparency, and interpretability.

Our framework integrates trajectory segmentation with the three modules of GL, representation learning, feature learning, and supervised decision making. The segmentation stage divides each swimming path into overlapping sub-trajectories, allowing fine-grained behavioral classification rather than treating the entire trial as a single unit. We then extract geometric and temporal features, which serve as inputs for representation learning. Subsequently, Discriminant Feature Test (DFT) and Least-squares Normal Transform (LNT) modules identify the most informative and interpretable features for distinguishing strategies. Finally, Subspace Learning Machines (SLM) and ensemble classifiers perform supervised decision learning with minimal computational cost.

Through this interpretable and sustainable approach, we aim to uncover subtle behavioral differences between experimental and control groups while reducing energy consumption and improving transparency in AI-driven behavioral analysis. The proposed framework not only advances rodent behavioral [...]

By |November 2nd, 2025|News|Comments Off on MCL Research on Mice Navigation Pattern Strategies|

MCL Research on 3D Whole-Brain Image Analysis in Mice

Mouse brains are often used as model systems in medical studies, as they share many similarities with the human brain in function and structure. By observing biomarkers in brain tissue, researchers can gain insight into how neurons and blood vessels interact to support processes such as learning, memory, and sensory perception (especially to triggers of content/stress and so on).

Our studies on 3D microscopic images of mouse brains involve two biomarkers: lectin and cFOS. Lectin is a protein which binds specifically to certain sugar molecules on the surface of cells lining blood vessels, and can therefore be stained with a fluorescent dye to mark the network of blood vessels. cFOS labelling, on the other hand, marks neurons that were recently active, serving as an “activity map” of brain regions responding to external stimuli or behavioural tasks. The detailed information of both biomarkers is obtained through the dissection of the mouse (especially cFOS, which requires observation around 2 hours after stimulation), which means that it cannot be observed through imaging of the human brain.

These datasets are typically large per brain, high-dimensional, and require pixel-level interpretation. Manual labelling for such data is often time-consuming, and could vary depending on the experience level of the person labelling. A single brain can produce gigabytes to terabytes of 3D imaging data, containing complex vessel networks and cellular activation patterns. As cFOS shows up as very small points on the image, labelling those accurately proves to be difficult in practice as well.

Green learning offers an efficient method for automatically segmenting and analysing these complex images. Deep learning often demands extensive labelled data and computational resources, and such data is often hard to find when it comes to medical applications. In contrast, [...]

By |October 26th, 2025|News|Comments Off on MCL Research on 3D Whole-Brain Image Analysis in Mice|

MCL Research on EEG Analysis

Our study focuses on EEG-based analysis of Alzheimer’s disease (AD) and related disorders using a Green-Computing AI framework. The method relies on coherence matrices to quantify functional connectivity between 19 scalp electrodes across five standard frequency bands (delta, theta, alpha, beta, gamma). Each coherence matrix reflects the degree of synchronization between pairs of brain regions, providing a compact representation of neural interaction patterns.

After computing the coherence matrices, we apply the Discriminant Feature Test (DFT) to identify the most informative features for distinguishing disease groups. DFT ranks all coherence features according to their discriminative power, measured by entropy-based separability across classes. The top-ranked (K_n) features from the upper triangle of the matrix are retained as raw discriminative features.

For each electrode pair with at least (m) (1 < m ≤ 5) selected band features, we further derive two complementary representations:

Linear Normal Transform (LNT) features, which map the selected coherence values into a linearly separable subspace; and

Support Vector Machine (SVM) features, which capture nonlinear decision boundaries between classes.

The final feature vector combines the selected raw, LNT, and SVM features. Three binary classifiers—AD vs CN, AD vs FTD, and FTD vs CN—are trained using a leave-one-out cross-validation scheme. For each test subject, the outputs from the relevant binary classifiers are averaged to form the final multi-class prediction.

By |October 19th, 2025|News|Comments Off on MCL Research on EEG Analysis|

MCL Research on Green Modulation Classification

The rapid evolution of 5G and emerging 6G networks creates an urgent need for intelligent, adaptive, and energy-efficient solutions that can operate at the edge under strict compute and power constraints. Current deep learning approaches are accurate but computationally expensive, limiting deployment in real-world embedded systems.

In this study, we introduce an efficient and transparent green learning pipeline designed to address the Automatic Modulation Classification (AMC) problem which is essential for cognitive radio. The goal of this pipeline is to enable wireless receivers to blindly identify modulation schemes of incoming signals in a computationally efficient manner while maintaining a compact model size suitable for deployment on edge or embedded systems. Our proposed approach consists of three main stages. First, the input signal is converted into a precise intermediate representation using a sparse coding method, which captures essential structural and statistical characteristics while suppressing redundant information. Second, we extract a diverse set of informative features from this sparse representation and the original signal statistics to ensure robustness against channel distortions and noise variations. Finally, a hierarchical classification subspace is constructed based on a tree-structured model, allowing the system to progressively distinguish between modulation categories with minimal computational burden.

By |October 12th, 2025|News|Comments Off on MCL Research on Green Modulation Classification|

Welcome New MCL Member Li-Heng Wang

We are very happy to welcome a new MCL member, Li-Heng Wang. Here is a quick interview with Li-Heng:

1. Could you briefly introduce yourself and your research interests?My name is Li-Heng Wang, and I am a first-year Ph.D. student in Computer Science at USC. My research interests lie in machine learning, image processing, and 3D vision. Outside of academics, I enjoy watching movies and sports games, working out, reading mystery novels and psychology books, and playing Go games with AI.2. What is your impression of MCL and USC?My experience with the MCL group has been impressive. It’s a community of brilliant, kind, and supportive researchers, and I’m already learning a lot from the senior members. I’m excited to be advised by Professor Kuo. The beautiful USC campus and welcoming atmosphere truly make me feel part of the Trojan Family.3. What is your future expectation and plan in MCL?My primary Ph.D. focus will be 3D vision, aiming to develop practical solutions for real-world deployment challenges. My central goal is to produce insightful and meaningful research for the academic community. I look forward to connecting with peers across different areas and building strong working relationships within the MCL group.

By |October 5th, 2025|News|Comments Off on Welcome New MCL Member Li-Heng Wang|

Welcome New MCL Member Claire Wang

We are very happy to welcome a new MCL member, Claire Wang. Here is a quick interview with Claire:

1. Could you briefly introduce yourself and your research interests?My name is Claire Wang, and I am currently a Ph.D. student in Electrical Engineering at USC. I received my bachelor’s degree from National Taiwan University (NTU). My research interests include machine learning and image processing, especially their applications in interdisciplinary problems. Outside of academics, I enjoy traveling, reading, singing and photography.

2. What is your impression of MCL and USC?My impression of MCL lab is that it provides a highly collaborative, strong and warm community where students are encouraged to explore research ideas under the guidance of experienced mentors. USC feels very dynamic and diverse, offering not only strong academic resources but also opportunities to connect with people from different cultural and professional backgrounds.

3. What is your future expectation and plan in MCL?

In MCL, I hope to build strong interactions with lab members, exchange ideas and collaborate on projects. I also look forward to learning from both Professor Kuo and my peers, not only to strengthen my research abilities but also to broaden my perspectives. I would like to gain a deeper understanding of Green Learning, explore its applications, and steadily contribute to the lab’s progress.

By |September 28th, 2025|News|Comments Off on Welcome New MCL Member Claire Wang|
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    Wei Wang, Jie-En Yao, Xinyu Wang, Haiyi Li, Vasileios Magoulianitis Attended ICIP 2025

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Wei Wang, Jie-En Yao, Xinyu Wang, Haiyi Li, Vasileios Magoulianitis Attended ICIP 2025

The IEEE International Conference on Image Processing (ICIP 2025), “Imaging in the Age of GenAI”, took place from September 14 to 18, 2025, in Anchorage, Alaska, USA. ICIP this year features a robust program of keynote lectures, oral and poster presentations, and workshops covering the latest breakthroughs in signal and image processing. It places a strong focus on machine learning and its subfields as a core driving force in image and video processing. Biomedical imaging continues to be a major area of interest. The conference is interested in traditional medical imaging and medical image analysis, but also in emerging biological image analysis and biomedical signal processing methods. Another major thematic area is computational imaging and related hardware-algorithm co-design. Topics include sparse, low-rank, and low-dimensional modeling; optimization-based inverse problem methods; sensor fusion; novel acquisition modalities. There is also interest in methods that quantify uncertainty and performance in computational imaging. Image and video techniques of representation, processing, analysis, and retrieval are also broadly covered.

MCL members presented four works in ICIP 2025, including “MA-YOLO: Video Object Detection via Motion-assisted YOLO” (by Xinyu Wang), “A Green Learning Approach to LDCT Image Restoration” (by Wei Wang), “MXB: Multi-stage XGboost for Efficient Tree-based Gradient Boosting” (by Haiyi Li), “SHFE: Transparent and Green Image Classification via Supervised Hierarchical Feature Extraction” (by Jie-En Yao). The works we proposed involves the fundamental learning module study as well as approaches following the Green Learning scheme to important applications in image and video processing. The principle of our proposed methods mainly lies in mathematical transparency, competitive performance, and outstanding efficiency in space and time complexity.

In addition to pioneering academic presentations, ICIP also offered professional development and networking opportunities, such as technical tutorials, industry workshops, student [...]

By |September 21st, 2025|News|Comments Off on Wei Wang, Jie-En Yao, Xinyu Wang, Haiyi Li, Vasileios Magoulianitis Attended ICIP 2025|
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    Congratulations to Aolin Feng for Passing His Qualifying Exam

Congratulations to Aolin Feng for Passing His Qualifying Exam

Congratulations to Aolin Feng for passing his Qualifying Exam! His thesis proposal is titled “ Green Image Coding: Principle, Implementation, and Performance Evaluation.” His Qualifying Exam Committee members include Jay Kuo (Chair), Antonio Ortega, Bhaskar Krishnamachari, Feng Qian, and Shanghao Teng (Outside Member). Here is a summary of his thesis proposal:

Image compression has long been dominated by two paradigms: the hybrid coding framework that adopts prediction and transform followed by scalar quantization, and deep learning-based codecs that leverage end-to-end optimization. While hybrid codecs offer reliable rate–distortion (RD) performance, they face a bottleneck for RD gain when integrating additional coding tools. In contrast, deep learning-based codecs achieve superior RD performance through end-to-end optimization but often suffer from high computational cost, especially for the decoder side.

The thesis proposal introduces Green Image Coding (GIC), a novel framework aiming for lightweight, RD-efficient, and scalable image compression. Different from the hybrid and deep learning-based coding, GIC is built upon two key designs: multigrid representation and vector quantization (VQ). The multigrid representation decomposes images into hierarchical layers, redistributing energy and reducing intra-layer content diversity. Each layer is then encoded using VQ-based techniques. 

Regarding the two key designs, we contribute both theoretical foundations and practical solutions: multigrid rate control and a set of advanced VQ techniques. For the multigrid rate control, we develop a theory that reduces a high-dimensional optimization to equivalent sequential parameter decisions, with comprehensive experimental validation. The theoretical conclusion guides the design of our rate control strategy, which improves the scalability and balance between rate and distortion. For the advanced VQ techniques, we start with tree-structured vector quantization (TSVQ) to build multi-rate coding capability, and propose an RD-oriented VQ codebook construction method. We also propose the cascade VQ strategy to tackle the [...]

By |September 14th, 2025|News|Comments Off on Congratulations to Aolin Feng for Passing His Qualifying Exam|